The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals

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ID: 299696
2006
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Ranked #106 of 125 articles by views in toxicological sciences : an official journal of the society of toxicology

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Abstract
The U.S. Environmental Protection Agency (EPA) is developing methods for utilizing computational chemistry, high-throughput screening (HTS), and various toxicogenomic technologies to predict potential for toxicity and prioritize limited testing resources toward chemicals that likely represent the greatest hazard to human health and the environment. This chemical prioritization research program, entitled "ToxCast," is being initiated with the purpose of developing the ability to forecast toxicity based on bioactivity profiling. The proof-of-concept phase of ToxCast will focus upon chemicals with an existing, rich toxicological database in order to provide an interpretive context for the ToxCast data. This set of several hundred reference chemicals will represent numerous structural classes and phenotypic outcomes, including tumorigens, developmental and reproductive toxicants, neurotoxicants, and immunotoxicants. The ToxCast program will evaluate chemical properties and bioactivity profiles across a broad spectrum of data domains: physical-chemical, predicted biological activities based on existing structure-activity models, biochemical properties based on HTS assays, cell-based phenotypic assays, and genomic and metabolomic analyses of cells. These data will be generated through a series of external contracts, along with collaborations across EPA, with the National Toxicology Program, and with the National Institutes of Health Chemical Genomics Center. The resulting multidimensional data set provides an informatics challenge requiring appropriate computational methods for integrating various chemical, biological, and toxicological data into profiles and models predicting toxicity.
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Authors David J. Dix, Keith A. Houck, Matthew T. Martin, Ann M. Richard, R. Woodrow Setzer, Robert J. Kavlock
Journal toxicological sciences : an official journal of the society of toxicology
Year 2006
DOI
10.1093/toxsci/kfl103
URL
https://doi.org/10.1093/toxsci/kfl103
Keywords Keywords not found

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