Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

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ID: 299475
1984
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Abstract
We report the complete nucleotide sequence of a human β actin cDNA. Both the 5′ and 3′ untranslated regions of the sequence are similar (>80%) to the analogous regions of the rat β-actin gene reported by Nudel et al (1983) 1 . When a segment of the 3′ untranslated region is used as a radiolabelled probe, strong hybridization to chick β actin mRNA is seen. This conservation of sequences suggests that strong selective pressures operate on non-translated segments of β actin mRNA.
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openalex_W2092602709 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Phyllis Ponte, S Y Ng, Joanne N. Engel, Peter W. Gunning, Larry Kedes
Journal Nucleic Acids Research
Year 1984
DOI
10.1093/nar/12.3.1687
URL
https://doi.org/10.1093/nar/12.3.1687
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