Combining Radiotherapy and Cancer Immunotherapy: A Paradigm Shift

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ID: 299404
2013
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Abstract
The therapeutic application of ionizing radiation has been largely based on its cytocidal power combined with the ability to selectively target tumors. Radiotherapy effects on survival of cancer patients are generally interpreted as the consequence of improved local control of the tumor, directly decreasing systemic spread. Experimental data from multiple cancer models have provided sufficient evidence to propose a paradigm shift, whereby some of the effects of ionizing radiation are recognized as contributing to systemic antitumor immunity. Recent examples of objective responses achieved by adding radiotherapy to immunotherapy in metastatic cancer patients support this view. Therefore, the traditional palliative role of radiotherapy in metastatic disease is evolving into that of a powerful adjuvant for immunotherapy. This combination strategy adds to the current anticancer arsenal and offers opportunities to harness the immune system to extend survival, even among metastatic and heavily pretreated cancer patients. We briefly summarize key evidence supporting the role of radiotherapy as an immune adjuvant. A critical appraisal of the current status of knowledge must include potential immunosuppressive effects of radiation that can hamper its capacity to convert the irradiated tumor into an in situ, individualized vaccine. Moreover, we discuss some of the current challenges to translate this knowledge to the clinic as more trials testing radiation with different immunotherapies are proposed.
Reference Key
openalex_W2140828776 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Silvia C. Formenti, Sandra Demaria
Journal JNCI Journal of the National Cancer Institute
Year 2013
DOI
10.1093/jnci/djs629
URL
https://academic.oup.com/jnci/article-pdf/105/4/256/25041090/djs629.pdf
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