Breast Tumor Cell Lines From Pleural Effusions2

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ID: 299365
1974
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Abstract
Summary During 1973, 4 new epithelial tumor cell lines were isolated from pleural effusions from breast cancer patients. We describe 3 of these lines: MDA-MB-134, with a mean chromosome number of 43; MDA-MB-175, with a mean chromosome number of 49; and MDA-MB-231, with a mean chromosome number between 65 and 69. We isolated the same cell type from 4 of 10 effusions from MDA-MB-134 and from 6 of 8 effusions from MDA-MB-175. We found that pleural effusions as a source of breast tumor cells to be cultured and studied in vitro have the following advantages: 1) large amounts of material and the possibility of obtaining sequential samples from the same patient; 2) high viability of tumor cells; 3) scarcity or absence of fibroblasts; and 4) the possibility of separating the tumor cells from other “contaminating” cell types by differences in their speed or degree of attachment to the flask. All lines from different patients differed, as seen grossly and microscopically. All lines from sequential pleural effusions from the same patient were apparently alike. No viruses or mycoplasmas were detected in any line.
Reference Key
openalex_W2255395527 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Relda Cailleau, Russell K. Young, Matilde Olivé, William J. Reeves
Journal JNCI Journal of the National Cancer Institute
Year 1974
DOI
10.1093/jnci/53.3.661
URL
https://doi.org/10.1093/jnci/53.3.661
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