Increasing Mortality Due to End-Stage Liver Disease in Patients with Human Immunodeficiency Virus Infection

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ID: 299308
2001
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Ranked #308 of 635 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract
Highly active antiretroviral therapy has decreased human immunodeficiency virus (HIV)-associated mortality; other comorbidities, such as chronic liver disease, are assuming greater importance. We retrospectively examined the causes of death of HIV-seropositive patients at our institution in 1991, 1996, and 1998–1999. In 1998–1999, 11 (50%) of 22 deaths were due to end-stage liver disease, compared with 3 (11.5%) of 26 in 1991 and 5 (13.9%) of 36 in 1996 (P = .003). In 1998–1999, 55% of patients had nondetectable plasma HIV RNA levels and/or CD4 cell counts of>200 cells/mm3 within the year before death. Most of the patients that were tested had detectable antibodies to hepatitis C virus (75% of patients who died in 1991, 57.7% who died in 1996, and 93.8% who died in 1998–1999; P = NS). In 1998–1999, 7 patients (31.8%) discontinued antiretroviral therapy because of hepatotoxicity, compared with 0 in 1991 and 2 (5.6%) in 1996. End-stage liver disease is now the leading cause of death in our hospitalized HIV-seropositive population.
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Authors Ioana Bica, Barbara McGovern, Ravi Dhar, David Stone, K. McGowan, Rochelle Scheib, David R. Snydman
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Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2001
DOI
10.1086/318501
URL
https://academic.oup.com/cid/article-pdf/32/3/492/798207/32-3-492.pdf
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