The BioGRID interaction database: 2017 update

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ID: 298981
2016
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Abstract
The Biological General Repository for Interaction Datasets (BioGRID: https://thebiogrid.org) is an open access database dedicated to the annotation and archival of protein, genetic and chemical interactions for all major model organism species and humans. As of September 2016 (build 3.4.140), the BioGRID contains 1 072 173 genetic and protein interactions, and 38 559 post-translational modifications, as manually annotated from 48 114 publications. This dataset represents interaction records for 66 model organisms and represents a 30% increase compared to the previous 2015 BioGRID update. BioGRID curates the biomedical literature for major model organism species, including humans, with a recent emphasis on central biological processes and specific human diseases. To facilitate network-based approaches to drug discovery, BioGRID now incorporates 27 501 chemical-protein interactions for human drug targets, as drawn from the DrugBank database. A new dynamic interaction network viewer allows the easy navigation and filtering of all genetic and protein interaction data, as well as for bioactive compounds and their established targets. BioGRID data are directly downloadable without restriction in a variety of standardized formats and are freely distributed through partner model organism databases and meta-databases.
Reference Key
openalex_W2915536738 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Andrew Chatr‐aryamontri, Rose Oughtred, Lorrie Boucher, Jennifer Rust, Christie Chang, Nadine K. Kolas, Lara O’Donnell, Sara Oster, Chandra L. Theesfeld, Adnane Sellam, Chris Stark, Bobby‐Joe Breitkreutz, Kara Dolinski, Mike Tyers
Journal Nucleic Acids Research
Year 2016
DOI
10.1093/nar/gkw1102
URL
https://doi.org/10.1093/nar/gkw1102
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