CDD: specific functional annotation with the Conserved Domain Database

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ID: 297761
2008
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Abstract
NCBI's Conserved Domain Database (CDD) is a collection of multiple sequence alignments and derived database search models, which represent protein domains conserved in molecular evolution. The collection can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml, and is also part of NCBI's Entrez query and retrieval system, cross-linked to numerous other resources. CDD provides annotation of domain footprints and conserved functional sites on protein sequences. Precalculated domain annotation can be retrieved for protein sequences tracked in NCBI's Entrez system, and CDD's collection of models can be queried with novel protein sequences via the CD-Search service at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi. Starting with the latest version of CDD, v2.14, information from redundant and homologous domain models is summarized at a superfamily level, and domain annotation on proteins is flagged as either 'specific' (identifying molecular function with high confidence) or as 'non-specific' (identifying superfamily membership only).
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Authors Aron Marchler‐Bauer, James B. Anderson, Farideh Chitsaz, Myra K. Derbyshire, C. DeWeese-Scott, Jessica H. Fong, Lewis Y. Geer, Renata C. Geer, Nicole R. Gonzales, Marya Gwadz, Susu He, David I. Hurwitz, John D. Jackson, Zhaoxi Ke, Christopher J. Lanczycki, C Liebert, C. Liu, Fuping Lu, Shuo Lu, Gabriele H. Marchler, Michael Mullokandov, James S. Song, A. Tasneem, Narmada Thanki, Roxanne A. Yamashita, Dapeng Zhang, Nong Zhang, Stephen H. Bryant
Journal Nucleic Acids Research
Year 2008
DOI
10.1093/nar/gkn845
URL
https://doi.org/10.1093/nar/gkn845
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