Chromosome Studies on Normal and Leukemic Human Leukocytes

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ID: 297749
1960
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Abstract
Chromosome studies were made on myeloblasts obtained from the peripheral blood of 4 patients (3 males, 1 female) with acute or chronic granulocytic leukemia and on leukocytes from 3 healthy individuals (1 male, 2 females). The cells were grown in culture for 2 to 4 days before examination. Both in normal and in leukemic cells, the predominant metaphase chromosome number was 46. However, idiogram analyses revealed a definite abnormality, probably involving the Y chromosome, in the 2 cases of chronic granulocytic leukemia. No chromosome abnormality was distinguishable in the 2 cases of acute leukemia (1 male, 1 female) investigated. The results indicate that in some leukemic human leukocytes small but definite chromosomal changes are demonstrable.
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openalex_W2275311108 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Peter C. Nowell̀, David A. Hungerford
Journal JNCI Journal of the National Cancer Institute
Year 1960
DOI
10.1093/jnci/25.1.85
URL
https://doi.org/10.1093/jnci/25.1.85
Keywords Keywords not found

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