MEGA: Molecular Evolutionary Genetics Analysis software for microcomputers

Clicks: 4
ID: 296981
1994
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Abstract
A computer program package called MEGA has been developed for estimating evolutionary distances, reconstructing phylogenetic trees and computing basic statistical quantities from molecular data. It is written in C++ and is intended to be used on IBM and IBM-compatible personal computers. In this program, various methods for estimating evolutionary distances from nucleotide and amino acid sequence data, three different methods of phylogenetic inference (UPGMA, neighbor-joining and maximum parsimony) and two statistical tests of topological differences are included. For the maximum parsimony method, new algorithms of branch-and-bound and heuristic searches are implemented. In addition, MEGA computes statistical quantities such as nucleotide and amino acid frequencies, transition/transversion biases, codon frequencies (codon usage tables), and the number of variable sites in specified segments in nucleotide and amino acid sequences. Advanced on-screen sequence data and phylogenetic-tree editors facilitate publication-quality outputs with a wide range of printers. Integrated and interactive designs, on-line context-sensitive helps, and a text-file editor make MEGA easy to use.
Reference Key
openalex_W2097403532 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sudhir Kumar, Koichiro Tamura, Masatoshi Nei
Journal BMC Bioinformatics
Year 1994
DOI
10.1093/bioinformatics/10.2.189
URL
https://doi.org/10.1093/bioinformatics/10.2.189
Keywords Keywords not found

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