GeneMANIA update 2018

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ID: 296978
2018
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Abstract
GeneMANIA (http://genemania.org) is a flexible user-friendly web site for generating hypotheses about gene function, analyzing gene lists and prioritizing genes for functional assays. Given a query gene list, GeneMANIA finds functionally similar genes using a wealth of genomics and proteomics data. In this mode, it weights each functional genomic dataset according to its predictive value for the query. Another use of GeneMANIA is gene function prediction. Given a single query gene, GeneMANIA finds genes likely to share function with it based on their interactions with it. Enriched Gene Ontology categories among this set can point to the function of the gene. Nine organisms are currently supported (Arabidopsis thaliana, Caenorhabditis elegans, Danio rerio, Drosophila melanogaster, Escherichia coli, Homo sapiens, Mus musculus, Rattus norvegicus and Saccharomyces cerevisiae). Hundreds of data sets and hundreds of millions of interactions have been collected from GEO, BioGRID, IRefIndex and I2D, as well as organism-specific functional genomics data sets. Users can customize their search by selecting specific data sets to query and by uploading their own data sets to analyze. We have recently updated the user interface to GeneMANIA to make it more intuitive and make more efficient use of visual space. GeneMANIA can now be used effectively on a variety of devices.
Reference Key
openalex_W2809000676 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Max Franz, Harold Rodriguez, Christian Lopes, Khalid Zuberi, Jason Montojo, Gary D. Bader, Quaid Morris
Journal Nucleic Acids Research
Year 2018
DOI
10.1093/nar/gky311
URL
https://academic.oup.com/nar/article-pdf/46/W1/W60/25110212/gky311.pdf
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