STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene

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Abstract
The repeated occurrence of genes in each other’s neighbourhood on genomes has been shown to indicate a functional association between the proteins they encode. Here we introduce STRING (search tool for recurring instances of neighbouring genes), a tool to retrieve and display the genes a query gene repeatedly occurs with in clusters on the genome. The tool performs iterative searches and visualises the results in their genomic context. By finding the genomically associated genes for a query, it delineates a set of potentially functionally associated genes. The usefulness of STRING is illustrated with an example that suggests a functional context for an RNA methylase with unknown specificity. STRING is available at http://www.bork.embl-heidelberg.de/STRING
Reference Key
openalex_W2145506897 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ‎Berend Snel
Journal Nucleic Acids Research
Year 2000
DOI
10.1093/nar/28.18.3442
URL
https://doi.org/10.1093/nar/28.18.3442
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