PRODIGY: a web server for predicting the binding affinity of protein–protein complexes

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ID: 296545
2016
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Abstract
Gaining insights into the structural determinants of protein-protein interactions holds the key for a deeper understanding of biological functions, diseases and development of therapeutics. An important aspect of this is the ability to accurately predict the binding strength for a given protein-protein complex. Here we present PROtein binDIng enerGY prediction (PRODIGY), a web server to predict the binding affinity of protein-protein complexes from their 3D structure. The PRODIGY server implements our simple but highly effective predictive model based on intermolecular contacts and properties derived from non-interface surface.PRODIGY is freely available at: http://milou.science.uu.nl/services/PRODIGY CONTACT: a.m.j.j.bonvin@uu.nl, a.vangone@uu.nl.
Reference Key
openalex_W2512372054 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Li C. Xue, João Rodrigues, Panagiotis L. Kastritis, Alexandre M. J. J. Bonvin, Anna Vangone
Journal BMC Bioinformatics
Year 2016
DOI
10.1093/bioinformatics/btw514
URL
https://academic.oup.com/bioinformatics/article-pdf/32/23/3676/13618823/btw514.pdf
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