Phenotype of Frailty: Characterization in the Women's Health and Aging Studies

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ID: 296238
2006
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Ranked #93 of 130 articles by views in the journals of gerontology series a, biological sciences and medical sciences

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Abstract
"Frailty" is an adverse, primarily gerontologic, health condition regarded as frequent with aging and having severe consequences. Although clinicians claim that the extremes of frailty can be easily recognized, a standardized definition of frailty has proved elusive until recently. This article evaluates the cross-validity, criterion validity, and internal validity in the Women's Health and Aging Studies (WHAS) of a discrete measure of frailty recently validated in the Cardiovascular Health Study (CHS).The frailty measure developed in CHS was delineated in the WHAS data sets. Using latent class analysis, we evaluated whether criteria composing the measure aggregate into a syndrome. We verified the criterion validity of the measure by testing whether participants defined as frail were more likely than others to develop adverse geriatric outcomes or to die.The distributions of frailty in the WHAS and CHS were comparable. In latent class analyses, the measures demonstrated strong internal validity vis à vis stated theory characterizing frailty as a medical syndrome. In proportional hazards models, frail women had a higher risk of developing activities of daily living (ADL) and/or instrumental ADL disability, institutionalization, and death, independently of multiple potentially confounding factors.The findings of this study are consistent with the widely held theory that conceptualizes frailty as a syndrome. The frailty definition developed in the CHS is applicable across diverse population samples and identifies a profile of high risk of multiple adverse outcomes.
Reference Key
openalex_W2152456824 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Karen Bandeen‐Roche, Qian‐Li Xue, Luigi Ferrucci, Jeremy Walston, Jack M. Guralnik, Paulo H. M. Chaves, Scott L. Zeger, Linda P. Fried
Journal the journals of gerontology series a, biological sciences and medical sciences
Year 2006
DOI
10.1093/gerona/61.3.262
URL
https://doi.org/10.1093/gerona/61.3.262
Keywords Keywords not found

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