On wollastonite and pseudo-wollastonite, polymorphic forms of calcium metasilicate, with optical study by F. E. Wright

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1906
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Abstract

Objective

To describe novel clinical features of GlyRα1-IgG–positive patients.

Methods

Patients with a positive serum GlyRα1-IgG were identified during a 2-year period from July 2016 to December 2018 at 2 academic centers and followed prospectively. All patients in this series were evaluated in the Neuroimmunology and Autoimmune Neurology clinics at the University of Utah or the University of Colorado.

Results

Thirteen of 17 patients had phenotypes more typically associated with glutamic acid decarboxylase (GAD65) antibody syndromes, consisting of stiff-person syndrome (SPS) with parkinsonism or cerebellar signs. One patient with parkinsonism had a presentation similar to rapidly progressive multiple system atrophy with severe dysautonomia. Ten of 17 patients had various visual symptoms including visual snow, spider web–like images forming shapes and 3-dimensional images, palinopsia, photophobia, visual hallucinations, synesthesia, and intermittent diplopia. Three of 17 patients presented with primarily autoimmune epilepsy accompanied by psychiatric symptoms.

Conclusions

Clinicians should consider testing for GlyR antibodies in GAD65 antibody–negative or low-positive GAD65 antibody patients with SPS-like presentations, especially in the setting of atypical features such as visual disturbances, parkinsonism, or epilepsy.
Reference Key
openalex_W2333126905 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors E. T. Allen, WESLEY WHITE, F. E. Wright
Journal american journal of science
Year 1906
DOI
10.2475/ajs.s4-21.122.89
URL
https://doi.org/10.2475/ajs.s4-21.122.89
Keywords Keywords not found

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