A horned artiodactyle (Protoceras celer) from the Miocene

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Abstract
Background: The main goal of this study was to evaluate the diagnostic efficacy of melanoma-associated antigen (MAGE) A1-6 reverse transcriptase-nested polymerase chain reaction (RT-nested PCR) of bronchial washing fluid for the detection of lung cancer invisible by bronchoscopy. Patients and Methods: To determine the expression of MAGE A1-6 gene in 75 lung carcinomas diagnosed by conventional fluoroscopy-guided lung biopsy and 58 cancer-free controls, RT-nested PCR was performed of bronchial washing fluid. MAGE A1-6 RT-nested PCR data was analyzed according to tumor histology, stage, size, and compared with cytological data. Results: MAGE A1-6 RT-nested PCR displayed higher sensitivity (64.0%) than that of conventional cytology (14.7%). There was no significant correlation between MAGE gene expression and histological types or clinical stage. For tumor size, detection rates were 74.0% in tumor smaller than 3 cm and 58.7% in these larger than 3 cm. Conclusions: MAGE A1-6 RT-nested PCR of bronchial washing fluid may be a useful method for diagnosis of peripheral lung cancer in clinical practice.
Reference Key
openalex_W2330283845 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors O. C. Marsh
Journal american journal of science
Year 1891
DOI
10.2475/ajs.s3-41.241.81
URL
https://doi.org/10.2475/ajs.s3-41.241.81
Keywords Keywords not found

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