Grove Karl Gilbert

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ID: 295492
1918
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Abstract

Abstract

Patterns of synaptic connectivity are remarkably precise and complex. Single-cell RNA sequencing has revealed a vast transcriptional diversity of neurons. Nevertheless, a clear logic underlying the transcriptional control of neuronal connectivity has yet to emerge. Here, we focused on Drosophila T4/T5 neurons, a class of closely related neuronal subtypes with different wiring patterns. Eight subtypes of T4/T5 neurons are defined by combinations of two patterns of dendritic inputs and four patterns of axonal outputs. Single-cell profiling during development revealed distinct transcriptional programs defining each dendrite and axon wiring pattern. These programs were defined by the expression of a few transcription factors and different combinations of cell surface proteins. Gain and loss of function studies provide evidence for independent control of different wiring features. We propose that modular transcriptional programs for distinct wiring features are assembled in different combinations to generate diverse patterns of neuronal connectivity.
Reference Key
openalex_W2316597711 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors W. M. Davis
Journal american journal of science
Year 1918
DOI
10.2475/ajs.s4-46.275.669
URL
https://doi.org/10.2475/ajs.s4-46.275.669
Keywords Keywords not found

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