Role for Interferon-γ in the Immunomodulatory Activity of Human Bone Marrow Mesenchymal Stem Cells
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ID: 295368
2005
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Abstract
Mesenchymal stem cells (MSCs) inhibit the proliferation of HLA-unrelated T lymphocytes to allogeneic stimulation, but the mechanisms responsible for this activity are not fully understood. We show here that MSCs suppress the proliferation of both CD4+ and CD8+ T lymphocytes, as well as of natural killer (NK) cells, whereas they do not have an effect on the proliferation of B lymphocytes. The antiproliferative effect of MSCs was not associated with any effect on the expression of cell-activation markers, induction of cell apoptosis, or mimicry/enhancement of T regulatory cell activity. The suppressive activity of MSCs was not contact-dependent and required the presence of interferon (IFN)-gamma produced by activated T cells and NK cells. Accordingly, even activated B cells became susceptible to the suppressive activity of MSCs in the presence of exogenously added IFN-gamma. The suppressive effect of IFN-gamma was related to its ability to stimulate the production by MSCs of indoleamine 2,3-dioxygenase activity, which in turn inhibited the proliferation of activated T or NK cells. These findings suggest that the beneficial effect on graft-versus-host disease induced by in vivo coinfusion with the graft of MSCs may be due to the activation of the immunomodulatory properties of MSCs by T cell- derived IFN-gamma.
| Reference Key |
openalex_W2019495971
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| Authors | Mauro Krampera, Lorenzo Cosmi, Roberta Angeli, Annalisa Pasini, Francesco Liotta, A Andreini, Veronica Santarlasci, Benedetta Mazzinghi, Giovanni Pizzolo, Fabrizio Vinante, Paola Romagnani, Enrico Maggi, Sergio Romagnani, Francesco Annunziato |
| Journal | stem cells international |
| Year | 2005 |
| DOI |
10.1634/stemcells.2005-0008
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| URL | |
| Keywords | Keywords not found |
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