NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS
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ID: 295295
1984
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Abstract
Observations that a pancreatic polypeptide-like substance, possibly neuropeptide Y, is present in hypothalamic areas and may coexist with catecholamines prompted evaluation of its role in controlling feeding behavior. Intracerebroventricular administration of 2 or 10 μg of human pancreatic polypeptide to ovariectomized rats pretreated with estradiol benzoate plus progesterone significantly increased the number of animals feeding, and total food intake in tests conducted during the light phase of the day. Administration of neuropeptide Y, 2 or 10 μg, induced feeding in all rats, and food intake was 3 times greater than that observed after human pancreatic polypeptide injection. These findings imply that neuropeptide Y, or a closely related pancreatic polypeptide-like neuropeptide, plays an important role in neural regulation of feeding behavior.
| Reference Key |
openalex_W2097378006
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| Authors | John T. Clark, Pushpa S. Kalra, William R. Crowley, Satya P. Kalra |
| Journal | american journal of physiology endocrinology and metabolism |
| Year | 1984 |
| DOI |
10.1210/endo-115-1-427
|
| URL | |
| Keywords | Keywords not found |
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