The intrusive mechanics of a clastic dike [Connecticut]

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ID: 295136
1950
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Abstract

Abstract

Emergence of the novel pathogenic coronavirus Sars-CoV-2 and its rapid pandemic spread presents numerous questions and challenges that demand immediate attention. Among these is the urgent need for a better understanding of humoral immune response against the virus and assessment of seroprevalence levels in the population, both of which form the basis for developing public health strategies to control viral spread. For this, sensitive, specific and quantitative serological assays are required. Here we describe the development of a semi-quantitative high-content microscopy-based assay for detection of three major classes (IgG, IgA and IgM) of SARS-CoV-2 specific antibodies in human samples. The possibility to detect antibodies against the entire viral proteome together with a robust semi-automated image analysis workflow resulted in improvement of sensitivity and specificity compared to an approved ELISA-based diagnostic test. Combining both methods resulted in maximum specificity in a negative control cohort, while maintaining high sensitivity. The procedure described here is compatible with high-throughput microscopy approaches and may be applied for serological analysis of other virus infections.
Reference Key
openalex_W2331147554 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors M. S. Walton, R. B. O'Sullivan
Journal american journal of science
Year 1950
DOI
10.2475/ajs.248.1.1
URL
https://doi.org/10.2475/ajs.248.1.1
Keywords Keywords not found

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