Relations among sodium borate hydrates at the Kramer deposit, Boron, California

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ID: 295120
1959
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Abstract

Background and aims

Increased levels of MMP-9 were reported in serum samples of SLE patients versus healthy controls, with the suggestion that MMP-9 plays a negative role in SLE.1-3 As a contrast, others demonstrated an inverse correlation between the levels of MMP-9 and anti-dsDNA in serum of SLE patients,4 the latter being a marker of disease severity. The double knock-out mice model B6lpr/lprMMP-9-/- mice shows reduced survival with extreme lymphadenopathy and splenomegaly, high lymphoproliferation, increased autoantibody (aAb) production and pronounced autoimmune tissue injury comparing with B6lpr/lpr.5 These data supports our suggestion that MMP-9 plays an important role in the clearance of autoantigens (aAg).5

Methods

Our present goal is to analyse if MMP-9 plays a role in immune complex (IC) clearance. Biochemical and molecular techniques

Results

Our data suggested that MMP-9 degrades aAg, coupled to immunoglobulins in IC, but the efficiency of cleavage depends of the nature of the IC. Our preclinical data in the B6lpr/lpr lupus animal model were validated with samples from SLE patients.

Conclusions

All these data may be interpreted in the way that MMP-9 acts as a protective factor in the development of the disease. Consequently, a profound study of the role of MMP-9 in SLE will generate new and interesting data about pathophysiology and progression of the disease and allow us to develop new effective treatment options

References

Clin Biochem 2008;41:955–9. Arthritis Res Ther 2004;6:R551–6. Arthritis Rheum 2004;50:858–65. Mol Pathol 2003;56:244–7. J Autoimmun 2011;36:239–52.
Reference Key
openalex_W2328558768 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors C. L. Christ, Robert M. Garrels
Journal american journal of science
Year 1959
DOI
10.2475/ajs.257.7.516
URL
https://doi.org/10.2475/ajs.257.7.516
Keywords Keywords not found

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