Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential

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ID: 294992
1988
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Abstract
We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200–204]
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Authors Patricia S. Steeg, Generoso Bevilacqua, L. Kópper, Unnur P. Thorgeirsson, James E. Talmadge, Lance A. Liotta, Mark E. Sobel
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Journal JNCI Journal of the National Cancer Institute
Year 1988
DOI
10.1093/jnci/80.3.200
URL
https://doi.org/10.1093/jnci/80.3.200
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