Intake of Carotenoids and Retino in Relation to Risk of Prostate Cancer

Clicks: 1
ID: 294573
1995
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #176 of 332 articles by views in JNCI Journal of the National Cancer Institute

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 332 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Background : Several human studies have observed a direct association between retinol (vitamin A) intake and risk of prostate cancer; other studies have found either an inverse association or no association of intake of β-carotene (the major provitamin A) with risk of prostate cancer. Data regarding carotenoids other than β-carotene in relation to prostate cancer risk are sparse. Purpose : We conducted a prospective cohort study to examine the relationship between the intake of various carotenoids, retinol, fruits, and vegetables and the risk of prostate cancer. Methods : Using responses to a validated, semiquantitative food-frequency questionnaire mailed to participants in the Health Professionals Follow-up Study in 1986, we assessed dietary intake for a 1-year period for a cohort of 47 894 eligible subjects initially free of diagnosed cancer. Follow-up questionnaires were sent to the entire cohort in 1988, 1990, and 1992. We calculated the relative risk (RR) for each of the upper categories of intake of a specific food or nutrient by dividing the incidence rate of prostate cancer among men in each of these categories by the rate among men in the lowest intake level. All P values resulted from two-sided tests. Results : Between 1986 and 1992, 812 new cases of prostate cancer, including 773 non-stage A1 cases, were documented. Intakes of the carotenoids β-carotene, α-carotene, lutein, and β-cryp-toxanthin were not associated with risk of non-stage A1 prostate cancer; only lycopene intake was related to lower risk (age- and energy-adjusted RR = 0.79; 95% confidence interval [CI] = 0.64–0.99 for high versus low quintile of intake; P for trend =.04). Of 46 vegetables and fruits or related products, four were significantly associated with lower prostate cancer risk; of the four— tomato sauce (P for trend =.001), tomatoes (P for trend =.03), and pizza (P for trend =.05), but not strawberries— were primary sources of lycopene. Combined intake of tomatoes, tomato sauce, tomato juice, and pizza (which accounted for 82% of lycopene intake) was inversely associated with risk of prostate cancer (multivariate RR = 0.65; 95% CI = 0.44–0.95, for consumption frequency greater than 10 versus less than 1.5 servings per week; P for trend =.01) and advanced (stages C and D) prostate cancers (multivariate RR = 0.47; 95% CI = 0.22–1.00; P for trend =.03). No consistent association was observed for dietary retinol and risk of prostate cancer. Conclusions : These findings suggest that intake of lycopene or other compounds in tomatoes may reduce prostate cancer risk, but other measured carotenoids are unrelated to risk. Implications : Our findings support recommendations to increase vegetable and fruit consumption to reduce cancer incidence but suggest that tomato-based foods may be especially beneficial regarding prostate cancer risk.
Reference Key
openalex_W2156585356 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors E. Giovannucci, Alberto Ascherio, E. B. Rimm, M. J. Stampfer, Graham A. Colditz, Walter C. Willett
Journal JNCI Journal of the National Cancer Institute
Year 1995
DOI
10.1093/jnci/87.23.1767
URL
https://doi.org/10.1093/jnci/87.23.1767
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.