Ice-dammed lavas from Clinker Mountain, southwestern British Columbia

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ID: 294231
1952
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Abstract
Tracheal cytotoxin (TCT), a monomer of DAP-type peptidoglycan from Bordetella pertussis, causes cytopathology in the respiratory epithelia of mammals and robustly triggers the Drosophila Imd pathway. PGRP-LE, a cytosolic innate immune sensor in Drosophila, directly recognizes TCT and triggers the Imd pathway, yet the mechanisms by which TCT accesses the cytosol are poorly understood. In this study, we report that CG8046, a Drosophila SLC46 family transporter, is a novel transporter facilitating cytosolic recognition of TCT, and plays a crucial role in protecting flies against systemic Escherichia coli infection. In addition, mammalian SLC46A2s promote TCT-triggered NOD1 activation in human epithelial cell lines, indicating that SLC46As is a conserved group of peptidoglycan transporter contributing to cytosolic immune recognition.
Reference Key
openalex_W2317182645 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors W. H. Mathews
Journal american journal of science
Year 1952
DOI
10.2475/ajs.250.8.553
URL
https://doi.org/10.2475/ajs.250.8.553
Keywords Keywords not found

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