Studies of superglacial debris on valley glaciers

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ID: 293139
1949
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Abstract
IL-4-dependent and -independent IgG1 Abs differ in their ability to induce mast cell degranulation as measured by passive cutaneous anaphylaxis (PCA). Mice immunized with OVA or PIII (fraction of Ascaris suum) produced high titers of IgG1 as shown by ELISA and PCA. In contrast, another A. suum fraction, PI, elicited IgG1 Abs with no PCA activity. IgG1 with anaphylactic activity required IL-4, as IgG1 responses to OVA and PIII in IL-4−/− mice gave no PCA. PI-specific IgG1 was IL-4-independent, because no difference was found between the responses of IL-4−/− and IL-4+/+ mice. Significant PCA reactions were elicited, however, with PI-specific IgG1 from IL-12−/− or anti-IFN-γ Ab-treated mice, although less Ab was measured by ELISA. These results indicate that one type of IgG1 has anaphylactic activity and its synthesis is IL-4-dependent, being inhibited by IL-12 or IFN-γ; the other lacks this activity and its synthesis is stimulated by IL-12 or IFN-γ.
Reference Key
openalex_W2329440701 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Richard Sharp
Journal american journal of science
Year 1949
DOI
10.2475/ajs.247.5.289
URL
https://doi.org/10.2475/ajs.247.5.289
Keywords Keywords not found

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