Theoretical prediction of the thermodynamic properties of aqueous electrolytes at high pressures and temperatures. III. Equation of state for aqueous species at infinite dilution

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ID: 292596
1976
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Abstract

Objective:

To investigate how monophasic acquired demyelinating syndromes (ADS) affect age-expected brain growth over time.

Methods:

We analyzed 83 pediatric patients imaged serially from initial demyelinating attack: 18 with acute disseminated encephalomyelitis (ADEM) and 65 with other monophasic ADS presentations (monoADS). We further subdivided the monoADS group by the presence (n = 33; monoADSlesion) or absence (n = 32; monoADSnolesion) of T2 lesions involving the brain at onset. We used normative data to compare brain volumes and calculate age- and sex-specific z scores, and used mixed-effect models to investigate their relationship with time from demyelinating illness.

Results:

Children with monophasic demyelination (ADEM, non-ADEM with brain lesions, and those without brain involvement) demonstrated reduced age-expected brain growth on serial images, driven by reduced age-expected white matter growth. Cortical gray matter volumes were not reduced at onset but demonstrated reduced age-expected growth afterwards in all groups. Brain volumes differed from age- and sex-expected values to the greatest extent in children with ADEM. All patient groups failed to recover age-expected brain growth trajectories.

Conclusions:

Brain volume, and more importantly age-expected brain growth, is negatively affected by acquired demyelination, even in the absence of chronicity, implicating factors other than active inflammation as operative in this process.
Reference Key
openalex_W2089588915 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Harold C. Helgeson, D. H. Kirkham
Journal american journal of science
Year 1976
DOI
10.2475/ajs.276.2.97
URL
https://ajs.scholasticahq.com/article/59827.pdf
Keywords Keywords not found

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