Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria

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ID: 292323
2017
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Abstract
Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic cells. Biofilm-based infections are, as a result, extremely difficult to cure. A wide range of molecular mechanisms contribute to the high degree of recalcitrance that is characteristic of biofilm communities. These mechanisms include, among others, interaction of antimicrobials with biofilm matrix components, reduced growth rates and the various actions of specific genetic determinants of antibiotic resistance and tolerance. Alone, each of these mechanisms only partially accounts for the increased antimicrobial recalcitrance observed in biofilms. Acting in concert, however, these defences help to ensure the survival of biofilm cells in the face of even the most aggressive antimicrobial treatment regimens. This review summarises both historical and recent scientific data in support of the known biofilm resistance and tolerance mechanisms. Additionally, suggestions for future work in the field are provided.
Reference Key
openalex_W2603755876 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Clayton W. Hall, Thien‐Fah Mah
Journal FEMS microbiology reviews
Year 2017
DOI
10.1093/femsre/fux010
URL
https://doi.org/10.1093/femsre/fux010
Keywords Keywords not found

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