Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?

Clicks: 4
ID: 292295
2007
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Abstract
Drug-induced severe cutaneous adverse reactions (SCARs) include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS), and epidermal necrolysis (Stevens-Johnson syndrome [SJS], toxic epidermal necrolysis). The identification of the causal drug is crucial in order to avoid further exposure, but making the right differential diagnosis of the type of SCAR is equally important since treatment, follow-up, and prognosis of different SCARs are not the same. These syndromes are distinct entities with different clinical, biological, and histological patterns, but sometimes the early distinction between 2 SCARs can be extremely challenging, and overlapping conditions could therefore be taken into consideration, although true overlapping SCARs are very rare when using strict diagnostic criteria (described by the RegiSCAR group). Only a better understanding of the physiopathology of the SCARs could possibly explain these ambiguities and overlaps. We report a case of SCAR in an 86-year-old patient probably induced by allopurinol and simultaneously fulfilling the diagnostic criteria for DRESS and SJS, thus considered as an overlapping case of SCARs.
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openalex_W2614087518 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sylvia H. Kardaun, Alexis Sidoroff, L. Valeyrie‐Allanore, Sima Halevy, Batya B. Davidovici, M Mockenhaupt, J.C. Roujeau
Journal the british journal of dermatology
Year 2007
DOI
10.1111/j.1365-2133.2006.07704.x
URL
https://doi.org/10.1111/j.1365-2133.2006.07704.x
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