MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

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ID: 291979
2011
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Abstract
Peptidases, their substrates and inhibitors are of great relevance to biology, medicine and biotechnology. The MEROPS database (http://merops.sanger.ac.uk) aims to fulfill the need for an integrated source of information about these. The database has hierarchical classifications in which homologous sets of peptidases and protein inhibitors are grouped into protein species, which are grouped into families, which are in turn grouped into clans. Recent developments include the following. A community annotation project has been instigated in which acknowledged experts are invited to contribute summaries for peptidases. Software has been written to provide an Internet-based data entry form. Contributors are acknowledged on the relevant web page. A new display showing the intron/exon structures of eukaryote peptidase genes and the phasing of the junctions has been implemented. It is now possible to filter the list of peptidases from a completely sequenced bacterial genome for a particular strain of the organism. The MEROPS filing pipeline has been altered to circumvent the restrictions imposed on non-interactive blastp searches, and a HMMER search using specially generated alignments to maximize the distribution of organisms returned in the search results has been added.
Reference Key
openalex_W2009393104 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Neil D. Rawlings, A. John Barrett, Alex Bateman
Journal Nucleic Acids Research
Year 2011
DOI
10.1093/nar/gkr987
URL
https://academic.oup.com/nar/article-pdf/40/D1/D343/9483848/gkr987.pdf
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