DIANA-miRPath v3.0: deciphering microRNA function with experimental support

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ID: 291786
2015
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Abstract
The functional characterization of miRNAs is still an open challenge.Here, we present DIANA-miRPath v3.0 (http://www.microrna.gr/miRPathv3)an online software suite dedicated to the assessment of miRNA regulatory roles and the identification of controlled pathways.The new miRPath web server renders possible the functional annotation of one or more miRNAs using standard (hypergeometric distributions), unbiased empirical distributions and/or meta-analysis statistics.DIANA-miRPath v3.0 database and functionality have been significantly extended to support all analyses for KEGG molecular pathways, as well as multiple slices of Gene Ontology (GO) in seven species (Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus and Danio rerio).Importantly, more than 600 000 experimentally supported miRNA targets from DIANA-TarBase v7.0 have been incorporated into the new schema.Users of DIANA-miRPath v3.0 can harness this wealth of information and substitute or combine the available in silico predicted targets from DIANA-microT-CDS and/or TargetScan v6.2 with high quality experimentally supported interactions.A unique feature of DIANA-miRPath v3.0 is its redesigned Reverse Search module, which enables users to identify and visualize miRNAs significantly controlling selected pathways or belonging to specific GO categories based on in silico or experimental data.DIANA-miRPath v3.0 is freely available to all users without any login requirement.
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openalex_W1609044025 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ioannis S. Vlachos, Konstantinos Zagganas, Maria D. Paraskevopoulou, Γεώργιος Γεωργακίλας, Dimitra Karagkouni, Thanasis Vergoulis, Theodore Dalamagas, Artemis G. Hatzigeorgiou
Journal Nucleic Acids Research
Year 2015
DOI
10.1093/nar/gkv403
URL
https://doi.org/10.1093/nar/gkv403
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