Circular dichroism and conformational polymorphism of DNA

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ID: 291664
2009
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Abstract
Here we review studies that provided important information about conformational properties of DNA using circular dichroic (CD) spectroscopy. The conformational properties include the B-family of structures, A-form, Z-form, guanine quadruplexes, cytosine quadruplexes, triplexes and other less characterized structures. CD spectroscopy is extremely sensitive and relatively inexpensive. This fast and simple method can be used at low- as well as high-DNA concentrations and with short- as well as long-DNA molecules. The samples can easily be titrated with various agents to cause conformational isomerizations of DNA. The course of detected CD spectral changes makes possible to distinguish between gradual changes within a single DNA conformation and cooperative isomerizations between discrete structural states. It enables measuring kinetics of the appearance of particular conformers and determination of their thermodynamic parameters. In careful hands, CD spectroscopy is a valuable tool for mapping conformational properties of particular DNA molecules. Due to its numerous advantages, CD spectroscopy significantly participated in all basic conformational findings on DNA.
Reference Key
openalex_W2116609429 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jaroslav Kypr, Iva Kejnovská, Daniel Renčiuk, Michaela Vorlı́čková
Journal Nucleic Acids Research
Year 2009
DOI
10.1093/nar/gkp026
URL
https://academic.oup.com/nar/article-pdf/37/6/1713/7698528/gkp026.pdf
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