Prevalence of quadruplexes in the human genome

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ID: 291641
2005
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Abstract
Abstract Guanine-rich DNA sequences of a particular form have the ability to fold into four-stranded structures called G-quadruplexes. In this paper, we present a working rule to predict which primary sequences can form this structure, and describe a search algorithm to identify such sequences in genomic DNA. We count the number of quadruplexes found in the human genome and compare that with the figure predicted by modelling DNA as a Bernoulli stream or as a Markov chain, using windows of various sizes. We demonstrate that the distribution of loop lengths is significantly different from what would be expected in a random case, providing an indication of the number of potentially relevant quadruplex-forming sequences. In particular, we show that there is a significant repression of quadruplexes in the coding strand of exonic regions, which suggests that quadruplex-forming patterns are disfavoured in sequences that will form RNA.
Reference Key
openalex_W2169745877 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors J Huppert, Shankar Balasubramanian
Journal Nucleic Acids Research
Year 2005
DOI
10.1093/nar/gki609
URL
https://doi.org/10.1093/nar/gki609
Keywords Keywords not found

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