RNAhybrid: microRNA target prediction easy, fast and flexible
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ID: 291435
2006
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Abstract
In the elucidation of the microRNA regulatory network, knowledge of potential targets is of highest importance. Among existing target prediction methods, RNAhybrid [M. Rehmsmeier, P. Steffen, M. Höchsmann and R. Giegerich (2004) RNA , 10 , 1507–1517] is unique in offering a flexible online prediction. Recently, some useful features have been added, among these the possibility to disallow G:U base pairs in the seed region, and a seed-match speed-up, which accelerates the program by a factor of 8. In addition, the program can now be used as a webservice for remote calls from user-implemented programs. We demonstrate RNAhybrid's flexibility with the prediction of a non-canonical target site for Caenorhabditis elegans miR-241 in the 3′-untranslated region of lin-39 . RNAhybrid is available at http://bibiserv.techfak.uni-bielefeld.de/rnahybrid .
| Reference Key |
openalex_W2154085311
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|---|---|
| Authors | Jan Walters Kruger, Marc Rehmsmeier |
| Journal | Nucleic Acids Research |
| Year | 2006 |
| DOI |
10.1093/nar/gkl243
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| URL | |
| Keywords | Keywords not found |
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