RNAhybrid: microRNA target prediction easy, fast and flexible

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ID: 291435
2006
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Abstract
In the elucidation of the microRNA regulatory network, knowledge of potential targets is of highest importance. Among existing target prediction methods, RNAhybrid [M. Rehmsmeier, P. Steffen, M. Höchsmann and R. Giegerich (2004) RNA , 10 , 1507–1517] is unique in offering a flexible online prediction. Recently, some useful features have been added, among these the possibility to disallow G:U base pairs in the seed region, and a seed-match speed-up, which accelerates the program by a factor of 8. In addition, the program can now be used as a webservice for remote calls from user-implemented programs. We demonstrate RNAhybrid's flexibility with the prediction of a non-canonical target site for Caenorhabditis elegans miR-241 in the 3′-untranslated region of lin-39 . RNAhybrid is available at http://bibiserv.techfak.uni-bielefeld.de/rnahybrid .
Reference Key
openalex_W2154085311 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jan Walters Kruger, Marc Rehmsmeier
Journal Nucleic Acids Research
Year 2006
DOI
10.1093/nar/gkl243
URL
Keywords Keywords not found

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