Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

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ID: 291272
1985
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Abstract
Full length cDns encoding the glycolyti enzme glyceraldehyde-3-phosphate dehyrogense (GAPDH)fron rat man have been in both genomes based on genmic blot hybridization analysis. Only one functional gene product is know. Result fron genomic library screeings suggest that are 300–400 copies of these sequences in the rat genome and approximately 100 in the human genome, Some of these realted sequences have been shown to be thesepseudogenes indicating that some pseudogenes are transcrined. Rat and human cDNA are 89% homologous in the coding region, and 76% homologous in the frist 100 base paris of the 3' -noncoding region. Comparison of these two cDNA sequences with those of the chicken, Drosophils and yeast genes allows analysis of the evolution of the GAPDH genes in detail.
Reference Key
openalex_W1997261857 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors J. Yun Tso, Xiao-Hong Sun, Teh‐hui Kao, Kimberly S. Reece, Ray Wu
Journal Nucleic Acids Research
Year 1985
DOI
10.1093/nar/13.7.2485
URL
https://doi.org/10.1093/nar/13.7.2485
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