miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database

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ID: 291253
2015
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Abstract
MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides, which negatively regulate the gene expression at the post-transcriptional level. This study describes an update of the miRTarBase (http://miRTarBase.mbc.nctu.edu.tw/) that provides information about experimentally validated miRNA-target interactions (MTIs). The latest update of the miRTarBase expanded it to identify systematically Argonaute-miRNA-RNA interactions from 138 crosslinking and immunoprecipitation sequencing (CLIP-seq) data sets that were generated by 21 independent studies. The database contains 4966 articles, 7439 strongly validated MTIs (using reporter assays or western blots) and 348 007 MTIs from CLIP-seq. The number of MTIs in the miRTarBase has increased around 7-fold since the 2014 miRTarBase update. The miRNA and gene expression profiles from The Cancer Genome Atlas (TCGA) are integrated to provide an effective overview of this exponential growth in the miRNA experimental data. These improvements make the miRTarBase one of the more comprehensively annotated, experimentally validated miRNA-target interactions databases and motivate additional miRNA research efforts.
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openalex_W2174734928 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chih‐Hung Chou, Nai-Wen Chang, Sirjana Shrestha, Sheng‐Da Hsu, Yu‐Ling Lin, Wei-Hsiang Lee, Chi-Dung Yang, Hsiao-Chin Hong, Ting-Yen Wei, Siang-Jyun Tu, Tzi-Ren Tsai, Shu-Yi Ho, Ting-Yan Jian, Hsin-Yi Wu, Pin-Rong Chen, Nai-Chieh Lin, Hsin-Tzu Huang, Tzu-Ling Yang, Chung-Yuan Pai, Chun-San Tai, Wenliang Chen, Chia‐Yen Huang, Chun-Chi Liu, Shun-Long Weng, Kuang‐Wen Liao, Wen-Lian Hsu, Hsien‐Da Huang
Journal Nucleic Acids Research
Year 2015
DOI
10.1093/nar/gkv1258
URL
https://academic.oup.com/nar/article-pdf/44/D1/D239/16661780/gkv1258.pdf
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