r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock

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ID: 291199
2003
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Abstract
Estimating divergence times and rates of substitution from sequence data is plagued by the problem of rate variation between lineages. R8s version 1.5 is a program which uses parametric, nonparametric and semiparametric methods to relax the assumption of constant rates of evolution to obtain better estimates of rates and times. Unlike most programs for rate inference or phylogenetics, r8s permits users to convert results to absolute rates and ages by constraining one or more node times to be fixed, minimum or maximum ages (using fossil or other evidence). Version 1.5 uses truncated Newton nonlinear optimization code with bound constraints, offering superior performance over previous versions.The linux executable, C source code, sample data sets and user manual are available free at http://ginger.ucdavis.edu/r8s.
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openalex_W2159368494 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Michael J. Sanderson
Journal BMC Bioinformatics
Year 2003
DOI
10.1093/bioinformatics/19.2.301
URL
https://doi.org/10.1093/bioinformatics/19.2.301
Keywords Keywords not found

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