The Variability of AOAC Methods of Analysis as Used in Analytical Pharmaceutical Chemistry

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ID: 291015
1977
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Abstract
Pharmaceutical analytical chemistry, which ordinarily deals with the analysis of formulations containing from 0.1 to 100% of active ingredient, uses methods with a reproducibility (between-laboratory variability) of about 2.5% and a repeatability (within-laboratory variability) of about half that amount. The best between-laboratory precision attainable appears to be about 1.0% and within-laboratory precision, about 0.5%. On the basis of the results available, automated methods do not appear to be any more precise than manual methods, although the studies show fewer outlying data points. Replicates (preferably blind ones) should always be conducted in a collaborative interlaboratory study in order to obtain the important information as to whether efforts should be concentrated on improving the method itself or on the performance of laboratories and analysis in applying it.
Reference Key
openalex_W24488698 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors William Horwitz
Journal journal of aoac international
Year 1977
DOI
10.1093/jaoac/60.6.1355
URL
https://doi.org/10.1093/jaoac/60.6.1355
Keywords Keywords not found

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