The Influence of Finasteride on the Development of Prostate Cancer
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ID: 290858
2021
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Abstract
This chapter describes the design, main findings, relevance, and limitations of the landmark Prostate Cancer Prevention Trial (PCPT), which randomized men to finasteride versus placebo and followed them for 7 years. It found a major reduction in prostate cancer incidence but also a higher proportion of high-risk cancer in men diagnosed with prostate cancer. The study did not address the more important oncological outcomes of disease-specific and overall survival. Secondary analyses of PCPT outcomes favored the finasteride arm and suggested that the risk of high-risk cancer is not increased. Linkage analysis of participants from PCPT to Medicare claims data suggested no adverse long-term cardiac, endocrine, or sexual effects.
| Reference Key |
openalex_W3135529189
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|---|---|
| Authors | Niranjan Sathianathen |
| Journal | Oxford University Press eBooks |
| Year | 2021 |
| DOI |
10.1093/med/9780190655341.003.0002
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| URL | |
| Keywords | Keywords not found |
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