The tRNAscan-SE, snoscan and snoGPS web servers for the detection of tRNAs and snoRNAs

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ID: 290693
2005
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Abstract
Transfer RNAs (tRNAs) and small nucleolar RNAs (snoRNAs) are two of the largest classes of non-protein-coding RNAs. Conventional gene finders that detect protein-coding genes do not find tRNA and snoRNA genes because they lack the codon structure and statistical signatures of protein-coding genes. Previously, we developed tRNAscan-SE, snoscan and snoGPS for the detection of tRNAs, methylation-guide snoRNAs and pseudouridylation-guide snoRNAs, respectively. tRNAscan-SE is routinely applied to completed genomes, resulting in the identification of thousands of tRNA genes. Snoscan has successfully detected methylation-guide snoRNAs in a variety of eukaryotes and archaea, and snoGPS has identified novel pseudouridylation-guide snoRNAs in yeast and mammals. Although these programs have been quite successful at RNA gene detection, their use has been limited by the need to install and configure the software packages on UNIX workstations. Here, we describe online implementations of these RNA detection tools that make these programs accessible to a wider range of research biologists. The tRNAscan-SE, snoscan and snoGPS servers are available at http://lowelab.ucsc.edu/tRNAscan-SE/ , http://lowelab.ucsc.edu/snoscan/ and http://lowelab.ucsc.edu/snoGPS/ , respectively.
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openalex_W2033713984 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Peter Schattner, A. N. Brooks, T. M. Lowe
Journal Nucleic Acids Research
Year 2005
DOI
10.1093/nar/gki366
URL
https://academic.oup.com/nar/article-pdf/33/suppl_2/W686/7622495/gki366.pdf
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