eggNOG-mapper v2: Functional Annotation, Orthology Assignments, and Domain Prediction at the Metagenomic Scale
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ID: 290106
2021
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Abstract
Even though automated functional annotation of genes represents a fundamental step in most genomic and metagenomic workflows, it remains challenging at large scales. Here, we describe a major upgrade to eggNOG-mapper, a tool for functional annotation based on precomputed orthology assignments, now optimized for vast (meta)genomic data sets. Improvements in version 2 include a full update of both the genomes and functional databases to those from eggNOG v5, as well as several efficiency enhancements and new features. Most notably, eggNOG-mapper v2 now allows for: 1) de novo gene prediction from raw contigs, 2) built-in pairwise orthology prediction, 3) fast protein domain discovery, and 4) automated GFF decoration. eggNOG-mapper v2 is available as a standalone tool or as an online service at http://eggnog-mapper.embl.de.
| Reference Key |
openalex_W3203343200
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| Authors | Carlos P. Cantalapiedra, Ana Hernández-Plaza, Ivica Letunić, Peer Bork, Jaime Huerta‐Cepas |
| Journal | molecular biology and evolution |
| Year | 2021 |
| DOI |
10.1093/molbev/msab293
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| URL | |
| Keywords | Keywords not found |
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