CDD: a Conserved Domain Database for the functional annotation of proteins

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ID: 290043
2010
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Abstract
NCBI’s Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from these footprints. CDD includes manually curated domain models that make use of protein 3D structure to refine domain models and provide insights into sequence/structure/function relationships. Manually curated models are organized hierarchically if they describe domain families that are clearly related by common descent. As CDD also imports domain family models from a variety of external sources, it is a partially redundant collection. To simplify protein annotation, redundant models and models describing homologous families are clustered into superfamilies. By default, domain footprints are annotated with the corresponding superfamily designation, on top of which specific annotation may indicate high-confidence assignment of family membership. Pre-computed domain annotation is available for proteins in the Entrez/Protein dataset, and a novel interface, Batch CD-Search, allows the computation and download of annotation for large sets of protein queries. CDD can be accessed via http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml .
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Authors Aron Marchler‐Bauer, Shuo Lu, J. B. Anderson, Farideh Chitsaz, Myra K. Derbyshire, C. DeWeese-Scott, Jessica H. Fong, Lewis Y. Geer, Renata C. Geer, Nicole R. Gonzales, Marya Gwadz, David I. Hurwitz, John David Jackson, Zhaoxi Ke, Christopher J. Lanczycki, Fuping Lu, Gabriele H. Marchler, Michael Mullokandov, Marina V. Omelchenko, Courtney Robertson, James S. Song, Narmada Thanki, Roxanne A. Yamashita, Dapeng Zhang, Nong Zhang, Chao Zheng, Stephen H. Bryant
Journal Nucleic Acids Research
Year 2010
DOI
10.1093/nar/gkq1189
URL
https://academic.oup.com/nar/article-pdf/39/suppl_1/D225/7633423/gkq1189.pdf
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