Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

Clicks: 5
ID: 289924
1984
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Star

Ranked #269 of 1,217 articles by views in Nucleic Acids Research

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 1,217 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
5′-Noncoding sequences have been tabulated for 211 messenger R'JAs from higher eukaryotic cells. The 5′-proximal AUG triplet serves as the initiator codon in 95% of the mRNAs examined. The most conspicuous conserved feature is the presence of a purine (most often A) three nucleotides upstream from the AUG initiator codon; only 6 of the mRNAs in the survey have a pyrimidine in that position. There is a predominance of C in positions −1, −2, −4 and −5, just upstream from the initiator codon. The sequence CCGACCAUG (G) thus emerges as a consensus sequence for eukaryotic initiation sites. The extent to which the ribosome binding site in a given mRNA matches the −1 to −5 consensus sequence varies: more than half of the mRNAs in the tabulation have 3 or 4 nucleotides in common with the CCACC consensus, but only ten mRNAs conform perfectly.
Reference Key
openalex_W2009105413 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Marilyn Kozak
Journal Nucleic Acids Research
Year 1984
DOI
10.1093/nar/12.2.857
URL
https://doi.org/10.1093/nar/12.2.857
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.