The HHpred interactive server for protein homology detection and structure prediction

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ID: 289805
2005
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Abstract
HHpred is a fast server for remote protein homology detection and structure prediction and is the first to implement pairwise comparison of profile hidden Markov models (HMMs). It allows to search a wide choice of databases, such as the PDB, SCOP, Pfam, SMART, COGs and CDD. It accepts a single query sequence or a multiple alignment as input. Within only a few minutes it returns the search results in a user-friendly format similar to that of PSI-BLAST. Search options include local or global alignment and scoring secondary structure similarity. HHpred can produce pairwise query-template alignments, multiple alignments of the query with a set of templates selected from the search results, as well as 3D structural models that are calculated by the MODELLER software from these alignments. A detailed help facility is available. As a demonstration, we analyze the sequence of SpoVT, a transcriptional regulator from Bacillus subtilis. HHpred can be accessed at http://protevo.eb.tuebingen.mpg.de/hhpred.
Reference Key
openalex_W2082667898 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Johannes Söding, A. Biegert, Andrei N. Lupas
Journal Nucleic Acids Research
Year 2005
DOI
10.1093/nar/gki408
URL
https://doi.org/10.1093/nar/gki408
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