The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications

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ID: 289775
1987
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Abstract
A simple, effective measure of synonymous codon usage bias, the Codon Adaptation Index, is detailed. The index uses a reference set of highly expressed genes from a species to assess the relative merits of each codon, and a score for a gene is calculated from the frequency of use of all codons in that gene. The index assesses the extent to which selection has been effective in moulding the pattern of codon usage. In that respect it is useful for predicting the level of expression of a gene, for assessing the adaptation of viral genes to their hosts, and for making comparisons of codon usage in different organisms. The index may also give an approximate indication of the likely success of heterologous gene expression.
Reference Key
openalex_W2018590530 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Paul M. Sharp, Wen‐Hsiung Li
Journal Nucleic Acids Research
Year 1987
DOI
10.1093/nar/15.3.1281
URL
https://doi.org/10.1093/nar/15.3.1281
Keywords Keywords not found

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