KEGG for integration and interpretation of large-scale molecular data sets

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ID: 289551
2011
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Abstract
Kyoto Encyclopedia of Genes and Genomes (KEGG, http://www.genome.jp/kegg/ or http://www.kegg.jp/) is a database resource that integrates genomic, chemical and systemic functional information. In particular, gene catalogs from completely sequenced genomes are linked to higher-level systemic functions of the cell, the organism and the ecosystem. Major efforts have been undertaken to manually create a knowledge base for such systemic functions by capturing and organizing experimental knowledge in computable forms; namely, in the forms of KEGG pathway maps, BRITE functional hierarchies and KEGG modules. Continuous efforts have also been made to develop and improve the cross-species annotation procedure for linking genomes to the molecular networks through the KEGG Orthology system. Here we report KEGG Mapper, a collection of tools for KEGG PATHWAY, BRITE and MODULE mapping, enabling integration and interpretation of large-scale data sets. We also report a variant of the KEGG mapping procedure to extend the knowledge base, where different types of data and knowledge, such as disease genes and drug targets, are integrated as part of the KEGG molecular networks. Finally, we describe recent enhancements to the KEGG content, especially the incorporation of disease and drug information used in practice and in society, to support translational bioinformatics.
Reference Key
openalex_W1998767819 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Minoru Kanehisa, Susumu Goto, Yoko Sato, Miho Furumichi, Mikio Tanabe
Journal Nucleic Acids Research
Year 2011
DOI
10.1093/nar/gkr988
URL
https://academic.oup.com/nar/article-pdf/40/D1/D109/9483865/gkr988.pdf
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