Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

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ID: 289531
2011
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Ranked #389 of 829 articles by views in BMC Bioinformatics

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Abstract
Summary: A combination of bisulfite treatment of DNA and high-throughput sequencing (BS-Seq) can capture a snapshot of a cell's epigenomic state by revealing its genome-wide cytosine methylation at single base resolution. Bismark is a flexible tool for the time-efficient analysis of BS-Seq data which performs both read mapping and methylation calling in a single convenient step. Its output discriminates between cytosines in CpG, CHG and CHH context and enables bench scientists to visualize and interpret their methylation data soon after the sequencing run is completed.
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openalex_W2131374955 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Felix Krueger, Simon Andrews
Journal BMC Bioinformatics
Year 2011
DOI
10.1093/bioinformatics/btr167
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