Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.

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ID: 289502
1986
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Abstract
Two simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions are presented. Although they give no weights to different types of codon substitutions, these methods give essentially the same results as those obtained by Miyata and Yasunaga's and by Li et al.'s methods. Computer simulation indicates that estimates of synonymous substitutions obtained by the two methods are quite accurate unless the number of nucleotide substitutions per site is very large. It is shown that all available methods tend to give an underestimate of the number of nonsynonymous substitutions when the number is large.
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openalex_W1907806866 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors M Nei, T Gojobori
Journal molecular biology and evolution
Year 1986
DOI
10.1093/oxfordjournals.molbev.a040410
URL
https://academic.oup.com/mbe/article-pdf/3/5/418/11167356/4nei.pdf
Keywords Keywords not found

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