SIFT: predicting amino acid changes that affect protein function

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ID: 289379
2003
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Abstract
Single nucleotide polymorphism (SNP) studies and random mutagenesis projects identify amino acid substitutions in protein-coding regions. Each substitution has the potential to affect protein function. SIFT (Sorting Intolerant From Tolerant) is a program that predicts whether an amino acid substitution affects protein function so that users can prioritize substitutions for further study. We have shown that SIFT can distinguish between functionally neutral and deleterious amino acid changes in mutagenesis studies and on human polymorphisms. SIFT is available at http://blocks.fhcrc.org/sift/SIFT.html.
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openalex_W2143238378 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors P.C. Ng
Journal Nucleic Acids Research
Year 2003
DOI
10.1093/nar/gkg509
URL
https://academic.oup.com/nar/article-pdf/31/13/3812/9487105/gkg509.pdf
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