tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic Sequence

Clicks: 4
ID: 289208
1997
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Abstract
We describe a program, tRNAscan-SE, which identifies 99–100% of transfer RNA genes in DNA sequence while giving less than one false positive per 15 gigabases. Two previously described tRNA detection programs are used as fast, first-pass prefilters to identify candidate tRNAs, which are then analyzed by a highly selective tRNA covariance model. This work represents a practical application of RNA covariance models, which are general, probabilistic secondary structure profiles based on stochastic context-free grammars. tRNAscan-SE searches at ∼30 000 bp/s. Additional extensions to tRNAscan-SE detect unusual tRNA homologues such as selenocysteine tRNAs, tRNA-derived repetitive elements and tRNA pseudo-genes.
Reference Key
openalex_W2149429041 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Todd M. Lowe, Sean R. Eddy
Journal Nucleic Acids Research
Year 1997
DOI
10.1093/nar/25.5.955
URL
https://doi.org/10.1093/nar/25.5.955
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