Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

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ID: 289154
2008
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Abstract
Functional analysis of large gene lists, derived in most cases from emerging high-throughput genomic, proteomic and bioinformatics scanning approaches, is still a challenging and daunting task. The gene-annotation enrichment analysis is a promising high-throughput strategy that increases the likelihood for investigators to identify biological processes most pertinent to their study. Approximately 68 bioinformatics enrichment tools that are currently available in the community are collected in this survey. Tools are uniquely categorized into three major classes, according to their underlying enrichment algorithms. The comprehensive collections, unique tool classifications and associated questions/issues will provide a more comprehensive and up-to-date view regarding the advantages, pitfalls and recent trends in a simpler tool-class level rather than by a tool-by-tool approach. Thus, the survey will help tool designers/developers and experienced end users understand the underlying algorithms and pertinent details of particular tool categories/tools, enabling them to make the best choices for their particular research interests.
Reference Key
openalex_W2133465414 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Da Wei Huang, Brad T. Sherman, Richard A. Lempicki
Journal Nucleic Acids Research
Year 2008
DOI
10.1093/nar/gkn923
URL
https://academic.oup.com/nar/article-pdf/37/1/1/17059338/gkn923.pdf
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