Synthesis, structural characterization, formation constants and in vitro cytotoxicity of phenanthroline and imidazolidine-2-thione copper(II) complexes.

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ID: 2840
2011
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Abstract
The synthesis, crystal structures, physicochemical properties and complex formation constants of [Cu(phen)(2)(L)](ClO(4))(2) complexes, where phen is 1,10-ortho-phenanthroline and L is a series of substituted imidazolidine-2-thione, have been studied. Single crystal X-ray diffraction revealed a distorted trigonal-bipyramidal geometry for all the molecules. The complex formation constants were determined in nonaqueous media by spectrophotometric measurements. Testing copper(II) complexes in mouse neuroblastoma N2a cells persistently infected with the 22L strain of the scrapie prion protein (22L-N2a) resulted in high cytotoxicity but no antiprion activity at nontoxic doses.
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pivetta2011synthesisjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Pivetta, Tiziana;Cannas, Maria Dolores;Demartin, Francesco;Castellano, Carlo;Vascellari, Sarah;Verani, Gaetano;Isaia, Francesco;
Journal Journal of inorganic biochemistry
Year 2011
DOI
10.1016/j.jinorgbio.2010.11.017
URL
Keywords Keywords not found

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